Tight control – decision-making during T cell–vascular endothelial cell interaction
نویسندگان
چکیده
منابع مشابه
Tight control – decision-making during T cell–vascular endothelial cell interaction
Vascular endothelial cells (ECs) form the inner layer of blood vessels and exert crucial functions during immune reactions including coagulation, inflammation, and regulation of innate immunity. Importantly, ECs can interact with T cells in an antigen-specific, i.e., T cell receptor-dependent manner. In this review, we will discuss EC actions and reactions during acute inflammation and focus on...
متن کاملLocal endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy
Cancer immunotherapy relies upon the ability of T cells to infiltrate tumors. The endothelium constitutes a barrier between the tumor and effector T cells, and the ability to manipulate local vascular permeability could be translated into effective immunotherapy. Here, we show that in the context of adoptive T cell therapy, antitumor T cells, delivered at high enough doses, can overcome the end...
متن کاملOrganizational Interaction Mechanisms Affecting Strategic Decision-Making During Cybercrime Investigations
The aim of this thesis is to understand and explain organizational interaction in law enforcement decision-making spheres, as a phenomenon that involves the concepts of collaboration, cooperation and information sharing, and the way that these affect cybercrime investigation processes. The problem research steams from the insufficient interdisciplinary work and theoretical developments of socia...
متن کاملAn oxygen sensitive self-decision making engineered CAR T-cell
A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely on the capacity to identify and target antigens with expression restrained to tumor cells. Here we present a strategy to generate CAR T-cells that are only effective locally (tumor tissue), potentially also increasing the choice of targetable antigens. By fusing an oxygen sensitive subdomain of HIF1α to ...
متن کاملMotor control is decision-making.
Motor behavior may be viewed as a problem of maximizing the utility of movement outcome in the face of sensory, motor and task uncertainty. Viewed in this way, and allowing for the availability of prior knowledge in the form of a probability distribution over possible states of the world, the choice of a movement plan and strategy for motor control becomes an application of statistical decision...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2012
ISSN: 1664-3224
DOI: 10.3389/fimmu.2012.00279